Revolutionizing Brain Health

Dr. Rudy Tanzi’s over four decades of innovative research have transformed brain health, from discovering the first Alzheimer’s disease genes to pioneering the discovery and development of effective and affordable treatments.

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For over four decades, Dr. Tanzi has been focused on a clear mission:

To preserve and promote healthy brain aging and prevent neurodegenerative disease through innovative research.

A Brighter Future for Brain Health

Dr. Tanzi’s groundbreaking discoveries are making brain fitness a priority, from helping to maintain brain health and mental acuity while pioneering lifestyle interventions and therapies to facilitate early prevention, detection, and prevention of Alzheimer’s and other neurodegenerative diseases.

Over 40 Years in Brain Health Innovation and Beyond

Dr. Tanzi has been advancing our understanding and the treatment of Alzheimer’s disease and other neurodegenerative diseases for over 40 years. He is the scientific founder of numerous biotech companies, including Acta Pharmaceuticals and React Neuro.

Time Magazine’s 100 Most Influential People in the World

Smithsonian Ingenuity Award Recipient

Member, National Academy of Medicine

Fellow, American Association for the Advancement of Arts and Sciences

Over 725 published research papers

New York Times best-selling author of four books

Time Magazine’s 100 Most Influential People in the World

Smithsonian Ingenuity Award Recipient

Member, National Academy of Medicine

Fellow, American Association for the Advancement of Arts and Sciences

Over 725 published research papers

New York Times best-selling author of four books

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Breakthroughs in Alzheimer’s Disease and Brain Health

1983

Helped find the Huntington’s disease gene (with Dr. James F. Gusella)​ – the first disease gene to ever be found by genetic linkage analysis 

1987

Discovered the first early-onset familial Alzheimer’s disease gene, the amyloid precursor protein (APP) 

1988

Constructed the first complete genetic map of a human chromosome  

1993

Provided the chromosome map that led to the first familial ALS (Lou Gehrig’s disease) gene (SOD-1) 

1993

Discovered the gene responsible for the neurodegenerative disease causing Wilson’s disease 

1994

Showed zinc and copper drive the formation of toxic amyloid in the brain leading to Alzheimer’s disease

1995

Co-discovered the second and third early-onset familial Alzheimer’s disease genes – presenilin 1 (PSEN1) and presenilin 2 (PSEN2) 

1996

On team that showed how the three early-onset familial Alzheimer’s disease genes lead to toxic brain amyloid and Alzheimer’s disease 

1998

Discovered the alpha-2 macroglobulin gene is associated with risk for late-onset Alzheimer’s disease 

1999

Reported the most common genetic risk factor for late-onset Alzheimer’s disease, Apolipoprotein E- e4, drives the aggregation of toxic beta-amyloid 

2000

Discovered genetic linkage of AD to chromosome 10 near the insulin degrading enzyme (IDE) gene 

2003

Conducted the first whole human genome genetic linkage study of late-onset familial Alzheimer’s disease 

2003

Reported the drug, clioquinol, blocks beta-amyloid formation and improves cognition in a phase 2 Alzheimer’s disease clinical trial 

2005

Discovered the LDL receptor-related protein (LRP) clears beta-amyloid 

2005

Discovered human autoantibodies to beta-amyloid that inspired the amyloid immunotherapies later approved to treat Alzheimer’s disease 

2005

Discovered the ubiquilin 1 gene is associated with risk for late-onset Alzheimer’s disease 

2006

Discovered the common inhalation anesthetic, isoflurane, increases brain levels of beta-amyloid that leads to Alzheimer’s disease 

2007

Established widely used gene databases (AlzGene, PDGene, SZGene) 

2008

Served on team that discovered one of the first autism genes 

2008

Reported the first familial Alzheimer’s disease genome-wide association study that led to the discovery of the first Alzheimer’s disease gene that implicated microglial cells and neuroinflammation in the disease process​ – CD33

2009

Discovered the Alzheimer’s disease gene, ADAM10, with mutations that increase beta-amyloid production 

2010

Discovered that the amyloid beta-protein serves as antimicrobial (host-defense) peptide in the brain leading to the Antimicrobial Protection Hypothesis of Alzheimer’s disease 

2010

Discovered beta-amyloid in the lens of Down syndrome and Alzheimer’s patients 

2010

Discovered the first potent gamma-secretase modulators (GSM) with Dr. Steve Wagner– now a clinical candidate slated for phase I clinical trials in 2025​ 

2012

Discovered that the “bobble-head” effect in bomb blast leads to traumatic brain injury and Alzheimer’s disease pathology (with Dr. Lee Goldstein) 

2013

Discovered CD33 controls beta-amyloid clearance and neuroinflammation in Alzheimer’s disease, making it a drug target

2014

Invented Alzheimer’s-in-a-Dish™, the first 3D human stem cell-derived neural culture AD model that fully recreates Alzheimer’s pathology​ and provides proof of concept that beta-amyloid causes tau tangles 

2016

Showed amyloid-beta protein can protect against infection by bacteria and fungus 

2016

Showed with Dr. Sam Sisodia that the gut microbiome can be modified to clear brain beta-amyloid in mice 

2017

Reported with Dr. Steve Wagner a highly potent gamma secretase that can lower the production of toxic Ab42 in the brain  

2018

Showed amyloid-beta protein can protect against herpes virus 1 (HSV1) infection  

2018

Reported exercise can restore cognitive function in Alzheimer’s disease mice and be mimicked with pharmacological treatments 

2019

Created the first 3D human cell culture blood brain barrier model of Alzheimer’s disease pathology 

2019

Showed the gene responsible for cerebellar ataxia (ATXN1) controls amyloid production in Alzheimer’s disease  

2019

Demonstrated that the two Alzheimer’s CD33 and TREM2 have opposite effects on the clearance of brain amyloid and neuroinflammation 

2020

Showed that cluster (oligomer) amyloid beta-protein directly induces tangle pathology in Alzheimer’s disease 

2020

Reported with Amylyx that the drug Relyvrio™ improves symptoms of ALS in phase 2 clinical trial, leading to subsequent approval 

2021

Discovered over a dozen new Alzheimer’s disease genes involved with synaptic function, using whole genome sequencing 

2021

Discovered with Dr. Filip Swirski that interleukin-3 could be used to reprogram microglia to clear beta-amyloid and reduce neuroinflammation 

2022

Co-founded Acta Pharmaceuticals with the mission of Empowering Minds and Ending Alzheimer's via development of drug therapies and natural supplements 

2022

Used whole-genome sequencing to discover two new genes associated with Alzheimer's disease

2022

Discovered a plasma cytokine biomarker profile that predicts cognitive trajectories in cognitively normal older adults

2023

With Dr. Can Zhang, developed HDAC6 inhibitors for the treatment of Alzheimer’s disease 

2023

With Dr. Amy Proal, showed that COVID can persist in body in specific organ reservoirs post-infection 

2023

Developed the McCance Center Brain Care Score™ with Dr. Jonathan Rosand 

2023

Demonstrated the role of T cells in exacerbating Alzheimer’s disease pathology

2023

Demonstrated the role of mast cells in exacerbating Alzheimer’s disease pathology 

2023

Showed that the muscle hormone, irisin, released during exercise, can trigger the enzymatic breakdown of beta-amyloid in the brain

2023

Identified known FDA-approved drugs and natural products that can reduce Alzheimer’s pathology – beta-amyloid and neuroinflammation

2024

Collaborated with Dr. Sam Sisodia and David Holtzman to show that the seaweed derived drug, GV-791 induces clearance of brain beta-amyloid

2024

Published a clinical trial showing sodium phenylbutyrate plus taurursodiol reduces spinal fluid biomarkers for Alzheimer’s pathology

2024

Developed the first poly-omic risk score to predict Alzheimer’s disease

2025

Discovered 16 new Alzheimer’s disease genes by studying diverse and multi-ethnic populations

2025

Published a clinical trial showing nicotinamide riboside (Niagen) reduces a blood biomarker (pTau-217) for Alzheimer’s plaques and tangles

Life Style

Make choices that protect your mind.

We’ve been told Alzheimer’s is an untreatable fate—but it’s not. Dr. Tanzi’s research shows that our lifestyle choices can compensate for 98-99% of genetic predisposition, allowing each individual to shape their brain health and risk for Alzheimer’s and related neurodegenerative disease as we age.

SHIELD Your Brain

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Transform Your
Understanding of the Brain

The Healing Self

The New York Times bestselling authors of Super Brain and Super Genes present a groundbreaking, landmark work on the supreme importance of protecting our immunity to ensure lifelong health.

“The Healing Self is a quantum leap forward in the integration of science, medicine, wisdom, and health.”—Arianna Huffington

In the face of environmental toxins, potential epidemics, superbugs, and the accelerated aging process, the significance of achieving optimum health has never been more crucial—and the burden to achieve it now rests on individuals making the right lifestyle choices every day.

That means you. You—not doctors, not pharmaceutical companies—are ultimately responsible for your own health.

Deepak Chopra and Rudolph E. Tanzi want to help readers make the best decisions possible when it comes to creating a holistic and transformative health plan for longevity. The Healing Self closely examines how we can best manage chronic stress and inflammation, which are emerging as the primary detriments to well-being. It also offers a cutting-edge seven-day action plan, which outlines the key tools everyone needs to develop their own effective and personalized path to self-healing.

The Healing Self, then, is a call to action, a proven, strategic program that will arm readers with the information they need to protect themselves and achieve lifelong wellness.

There is a new revolution unfolding in health today. That revolution is you.

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 The Healing Self by Rudolph E. Tanzi Ph.D. (Author), by Deepak Chopra
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Decoding Darkness

Working from the intriguing hypothesis that Alzheimer's dementia is the result of a renegade protein-beta amyloid-Tanzi and others set out to find the gene responsible for its production. Decoding Darkness takes us deep into the minds and far-flung labs of many a prominent researcher, offering an intimate view of the high stakes of molecular genetics, the revolution that propels it, the obstacles that threaten to derail it, and the families whose lives are so dependent upon it. Tanzi and Parson ultimately reveal that Alzheimer's, like heart disease, may be effectively treated-even prevented.

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Decoding Darkness by Rudolph E. Tanzi Ph.D. (Author), by Ann B. Parson (Author)
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Super Brain

A manual for relating to the brain in a revolutionary new way, Super Brain shows you how to use your brain as a gateway for achieving health, happiness, and spiritual growth.

Two pioneers, bestselling author and physician Deepak Chopra and Harvard Medical School professor Rudolph E. Tanzi, one of the world's foremost experts on the causes of Alzheimer’s, have merged their wisdom and expertise for a bold new understanding of the “three-pound universe” and its untapped potential.

In contrast to the “baseline brain” that fulfills the tasks of everyday life, Chopra and Tanzi propose that, through a person’s increased self-awareness and conscious intention, the brain can be taught to reach far beyond its present limitations. “We are living in a golden age for brain research, but is this a golden age for your brain?” they ask.

Super Brain explains how it can be, by combining cutting-edge research and spiritual insights, demolishing the five most widespread myths about the brain that limit your potential, and then showing you methods to:

-Use your brain instead of letting it use you
-Create the ideal lifestyle for a healthy brain
-Reduce the risks of aging
-Promote happiness and well-being through the mind-body connection
-Access the enlightened brain, the gateway to freedom and bliss
-Overcome the most common challenges, such as memory loss, depression, anxiety, and obesity

Your brain is capable of incredible healing and constant reshaping. Through a new relationship with your brain you can transform your life. In Super Brain, Chopra and Tanzi guide you on a fascinating journey that envisions a leap in human evolution. The brain is not just the greatest gift that Nature has given us. It’s the gateway to an unlimited future that you can begin to live today.

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Super Brain by Rudolph E. Tanzi Ph.D. (Author), by Deepak Chopra M.D. (Author)
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Super Genes

The authors of the New York Times bestseller Super Brain present a bold new understanding of our genes and how simple changes in lifestyle can boost genetic activity. The leap into "radical well-being" is a promise waiting to be fulfilled.

"You are not simply the sum total of the genes you were born with," writes Deepak Chopra and Rudy Tanzi. "You are the user and controller of your genes, the author of your biological story. No prospect in self-care is more exciting."

Learning how to shape your gene activity is at the heart of this exciting and eagerly-anticipated book from the bestselling duo behind Super Brain, which became a nationwide hit on public television.

For decades medical science has believed that genes determined our biological destiny. Now the new genetics has changed that assumption forever. You will always have the genes you were born with, but genes are dynamic, responding to everything we think, say, and do. Suddenly they've become our strongest allies for personal transformation. When you make lifestyle choices that optimize how your genes behave, you can reach for a state of health and fulfillment undreamed of even a decade ago. The impact on prevention, immunity, diet, aging, and chronic disorders is unparalleled.

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Super Genes by Rudolph E. Tanzi Ph.D. (Author), by Deepak Chopra M.D. (Author)
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