Revolutionizing Brain Health
Dr. Rudy Tanzi’s over four decades of innovative research have transformed brain health, from discovering the first Alzheimer’s disease genes to pioneering the discovery and development of effective and affordable treatments.
For over four decades, Dr. Tanzi has been focused on a clear mission:
To preserve and promote healthy brain aging and prevent neurodegenerative disease through innovative research.
A Brighter Future for Brain Health
Dr. Tanzi’s groundbreaking discoveries are making brain fitness a priority, from helping to maintain brain health and mental acuity while pioneering lifestyle interventions and therapies to facilitate early prevention, detection, and prevention of Alzheimer’s and other neurodegenerative diseases.
Discovery of the first three Alzheimer’s disease genes
Co-discovery of the three early-onset familial Alzheimer’s disease genes (APP, PSEN1, PSEN2), all pointing to deposition of beta-amyloid in the brain as the initial cause of the disease, leading to the amyloid hypothesis of Alzheimer’s disease.
Discovery of the genetic basis of the role of brain inflammation in Alzheimer’s disease
Discovery of the first Alzheimer’s gene, CD33, controlling clearance of brain amyloid and control of neuroinflammation in the brain.
Alzheimer’s-in-a-Dish™
The first mini-human brain organoid model that accurately recreates decades of Alzheimer’s Disease pathology in just six weeks, dramatically accelerating and revolutionizing drug discovery.
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Discovered natural products that reduce age-related brain pathology
Designed to help the brain clear away beta-amyloid that often accumulates in the normal aging brain and protect against neuroinflammation, the biggest killer of brain nerve cells.
Gamma Secretase Modulator (GSM)
A drug that reduces the production of the amyloid beta protein known as Abeta42, which accumulates in the aging brain and triggers Alzheimer’s disease pathology.
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The S.H.I.E.L.D. Plan for Brain Health
Lifestyle strategies and choices to support brain health and promote brain fitness based on Sleep, Handling Stress, Interaction with others, Exercise, Learning new things, and Diet.
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The McCance Center for Brain Health “Brain Care Score”
With Dr. Jonathan Rosand and Dr. Greg Fricchione, Dr. Tanzi co-founded the McCance Center for Brain Health, for which he serves as Director. The Center developed the Brain Care Score that allows one to assess one’s brain health based on indicators of cardiovascular health and practice of the S.H.I.E.L.D. plan.
CogniSHIELD Global LLC, in collaboration with Dr. Tanzi and his team, developed a dietary supplement, “CogniSHIELD™” chosen from over 3,500 natural supplements tested during 10 years of laboratory research.
Dr. Tanzi is a shareholder in CogniSHIELD Global LLC and an inventor on patents covering CogniSHIELD™, which are under a license agreement with The General Hospital Corporation (Massachusetts General Hospital).
For more information and to be directed to the CogniSHIELD™ website, click below:
Over 40 Years in Brain Health Innovation and Beyond
Dr. Tanzi has been advancing our understanding and the treatment of Alzheimer’s disease and other neurodegenerative diseases for over 40 years. He is the scientific founder of numerous biotech companies, including Acta Pharmaceuticals and React Neuro.
Time Magazine’s 100 Most Influential People in the World
Smithsonian Ingenuity Award Recipient
Member, National Academy of Medicine
Fellow, American Association for the Advancement of Arts and Sciences
Over 725 published research papers
New York Times best-selling author of four books
Time Magazine’s 100 Most Influential People in the World
Smithsonian Ingenuity Award Recipient
Member, National Academy of Medicine
Fellow, American Association for the Advancement of Arts and Sciences
Over 725 published research papers
New York Times best-selling author of four books
Breakthroughs in Alzheimer’s Disease and Brain Health
1983
Helped find the Huntington’s disease gene (with Dr. James F. Gusella) – the first disease gene to ever be found by genetic linkage analysis
1987
Discovered the first early-onset familial Alzheimer’s disease gene, the amyloid precursor protein (APP)
1988
Constructed the first complete genetic map of a human chromosome
1993
Provided the chromosome map that led to the first familial ALS (Lou Gehrig’s disease) gene (SOD-1)
1993
Discovered the gene responsible for the neurodegenerative disease causing Wilson’s disease
1994
Showed zinc and copper drive the formation of toxic amyloid in the brain leading to Alzheimer’s disease
1995
Co-discovered the second and third early-onset familial Alzheimer’s disease genes – presenilin 1 (PSEN1) and presenilin 2 (PSEN2)
1996
On team that showed how the three early-onset familial Alzheimer’s disease genes lead to toxic brain amyloid and Alzheimer’s disease
1998
Discovered the alpha-2 macroglobulin gene is associated with risk for late-onset Alzheimer’s disease
1999
Reported the most common genetic risk factor for late-onset Alzheimer’s disease, Apolipoprotein E- e4, drives the aggregation of toxic beta-amyloid
2000
Discovered genetic linkage of AD to chromosome 10 near the insulin degrading enzyme (IDE) gene
2003
Conducted the first whole human genome genetic linkage study of late-onset familial Alzheimer’s disease
2003
Reported the drug, clioquinol, blocks beta-amyloid formation and improves cognition in a phase 2 Alzheimer’s disease clinical trial
2005
Discovered the LDL receptor-related protein (LRP) clears beta-amyloid
2005
Discovered human autoantibodies to beta-amyloid that inspired the amyloid immunotherapies later approved to treat Alzheimer’s disease
2005
Discovered the ubiquilin 1 gene is associated with risk for late-onset Alzheimer’s disease
2006
Discovered the common inhalation anesthetic, isoflurane, increases brain levels of beta-amyloid that leads to Alzheimer’s disease
2007
Established widely used gene databases (AlzGene, PDGene, SZGene)
2008
Served on team that discovered one of the first autism genes
2008
Reported the first familial Alzheimer’s disease genome-wide association study that led to the discovery of the first Alzheimer’s disease gene that implicated microglial cells and neuroinflammation in the disease process – CD33
2009
Discovered the Alzheimer’s disease gene, ADAM10, with mutations that increase beta-amyloid production
2010
Discovered that the amyloid beta-protein serves as antimicrobial (host-defense) peptide in the brain leading to the Antimicrobial Protection Hypothesis of Alzheimer’s disease
2010
Discovered beta-amyloid in the lens of Down syndrome and Alzheimer’s patients
2010
Discovered the first potent gamma-secretase modulators (GSM) with Dr. Steve Wagner– now a clinical candidate slated for phase I clinical trials in 2025
2012
Discovered that the “bobble-head” effect in bomb blast leads to traumatic brain injury and Alzheimer’s disease pathology (with Dr. Lee Goldstein)
2013
Discovered CD33 controls beta-amyloid clearance and neuroinflammation in Alzheimer’s disease, making it a drug target
2014
Invented Alzheimer’s-in-a-Dish™, the first 3D human stem cell-derived neural culture AD model that fully recreates Alzheimer’s pathology and provides proof of concept that beta-amyloid causes tau tangles
2016
Showed amyloid-beta protein can protect against infection by bacteria and fungus
2016
Showed with Dr. Sam Sisodia that the gut microbiome can be modified to clear brain beta-amyloid in mice
2017
Reported with Dr. Steve Wagner a highly potent gamma secretase that can lower the production of toxic Ab42 in the brain
2018
Showed amyloid-beta protein can protect against herpes virus 1 (HSV1) infection
2018
Reported exercise can restore cognitive function in Alzheimer’s disease mice and be mimicked with pharmacological treatments
2019
Created the first 3D human cell culture blood brain barrier model of Alzheimer’s disease pathology
2019
Showed the gene responsible for cerebellar ataxia (ATXN1) controls amyloid production in Alzheimer’s disease
2019
Demonstrated that the two Alzheimer’s CD33 and TREM2 have opposite effects on the clearance of brain amyloid and neuroinflammation
2020
Showed that cluster (oligomer) amyloid beta-protein directly induces tangle pathology in Alzheimer’s disease
2020
Reported with Amylyx that the drug Relyvrio™ improves symptoms of ALS in phase 2 clinical trial, leading to subsequent approval
2021
Discovered over a dozen new Alzheimer’s disease genes involved with synaptic function, using whole genome sequencing
2021
Discovered with Dr. Filip Swirski that interleukin-3 could be used to reprogram microglia to clear beta-amyloid and reduce neuroinflammation
2022
Co-founded Acta Pharmaceuticals with the mission of Empowering Minds and Ending Alzheimer's via development of drug therapies and natural supplements
2022
Used whole-genome sequencing to discover two new genes associated with Alzheimer's disease
2022
Discovered a plasma cytokine biomarker profile that predicts cognitive trajectories in cognitively normal older adults
2023
With Dr. Can Zhang, developed HDAC6 inhibitors for the treatment of Alzheimer’s disease
2023
With Dr. Amy Proal, showed that COVID can persist in body in specific organ reservoirs post-infection
2023
Developed the McCance Center Brain Care Score™ with Dr. Jonathan Rosand
2023
Demonstrated the role of T cells in exacerbating Alzheimer’s disease pathology
2023
Demonstrated the role of mast cells in exacerbating Alzheimer’s disease pathology
2023
Showed that the muscle hormone, irisin, released during exercise, can trigger the enzymatic breakdown of beta-amyloid in the brain
2023
Identified known FDA-approved drugs and natural products that can reduce Alzheimer’s pathology – beta-amyloid and neuroinflammation
2024
Collaborated with Dr. Sam Sisodia and David Holtzman to show that the seaweed derived drug, GV-791 induces clearance of brain beta-amyloid
2024
Published a clinical trial showing sodium phenylbutyrate plus taurursodiol reduces spinal fluid biomarkers for Alzheimer’s pathology
2024
Developed the first poly-omic risk score to predict Alzheimer’s disease
2025
Discovered 16 new Alzheimer’s disease genes by studying diverse and multi-ethnic populations
2025
Published a clinical trial showing nicotinamide riboside (Niagen) reduces a blood biomarker (pTau-217) for Alzheimer’s plaques and tangles
Make choices that protect your mind.
We’ve been told Alzheimer’s is an untreatable fate—but it’s not. Dr. Tanzi’s research shows that our lifestyle choices can compensate for 98-99% of genetic predisposition, allowing each individual to shape their brain health and risk for Alzheimer’s and related neurodegenerative disease as we age.
Transform Your Understanding of the Brain
The Healing Self
by Rudolph E. Tanzi Ph.D. (Author), by Deepak Chopra M.D. (Author)
The New York Times bestselling authors of Super Brain and Super Genes present a groundbreaking, landmark work on the supreme importance of protecting our immunity to ensure lifelong health.
“The Healing Self is a quantum leap forward in the integration of science, medicine, wisdom, and health.”—Arianna Huffington
In the face of environmental toxins, potential epidemics, superbugs, and the accelerated aging process, the significance of achieving optimum health has never been more crucial—and the burden to achieve it now rests on individuals making the right lifestyle choices every day.
That means you. You—not doctors, not pharmaceutical companies—are ultimately responsible for your own health.
Deepak Chopra and Rudolph E. Tanzi want to help readers make the best decisions possible when it comes to creating a holistic and transformative health plan for longevity. The Healing Self closely examines how we can best manage chronic stress and inflammation, which are emerging as the primary detriments to well-being. It also offers a cutting-edge seven-day action plan, which outlines the key tools everyone needs to develop their own effective and personalized path to self-healing.
The Healing Self, then, is a call to action, a proven, strategic program that will arm readers with the information they need to protect themselves and achieve lifelong wellness.
There is a new revolution unfolding in health today. That revolution is you.

Decoding Darkness
by Rudolph E. Tanzi Ph.D. (Author), by Ann B. Parson (Author)Working from the intriguing hypothesis that Alzheimer's dementia is the result of a renegade protein-beta amyloid-Tanzi and others set out to find the gene responsible for its production. Decoding Darkness takes us deep into the minds and far-flung labs of many a prominent researcher, offering an intimate view of the high stakes of molecular genetics, the revolution that propels it, the obstacles that threaten to derail it, and the families whose lives are so dependent upon it. Tanzi and Parson ultimately reveal that Alzheimer's, like heart disease, may be effectively treated-even prevented.

Super Brain
by Rudolph E. Tanzi Ph.D. (Author), by Deepak Chopra M.D. (Author)
A manual for relating to the brain in a revolutionary new way, Super Brain shows you how to use your brain as a gateway for achieving health, happiness, and spiritual growth.
Two pioneers, bestselling author and physician Deepak Chopra and Harvard Medical School professor Rudolph E. Tanzi, one of the world's foremost experts on the causes of Alzheimer’s, have merged their wisdom and expertise for a bold new understanding of the “three-pound universe” and its untapped potential.
In contrast to the “baseline brain” that fulfills the tasks of everyday life, Chopra and Tanzi propose that, through a person’s increased self-awareness and conscious intention, the brain can be taught to reach far beyond its present limitations. “We are living in a golden age for brain research, but is this a golden age for your brain?” they ask.
Super Brain explains how it can be, by combining cutting-edge research and spiritual insights, demolishing the five most widespread myths about the brain that limit your potential, and then showing you methods to:
-Use your brain instead of letting it use you
-Create the ideal lifestyle for a healthy brain
-Reduce the risks of aging
-Promote happiness and well-being through the mind-body connection
-Access the enlightened brain, the gateway to freedom and bliss
-Overcome the most common challenges, such as memory loss, depression, anxiety, and obesity
Your brain is capable of incredible healing and constant reshaping. Through a new relationship with your brain you can transform your life. In Super Brain, Chopra and Tanzi guide you on a fascinating journey that envisions a leap in human evolution. The brain is not just the greatest gift that Nature has given us. It’s the gateway to an unlimited future that you can begin to live today.

Super Genes
by Rudolph E. Tanzi Ph.D. (Author), by Deepak Chopra M.D. (Author)
The authors of the New York Times bestseller Super Brain present a bold new understanding of our genes and how simple changes in lifestyle can boost genetic activity. The leap into "radical well-being" is a promise waiting to be fulfilled.
"You are not simply the sum total of the genes you were born with," writes Deepak Chopra and Rudy Tanzi. "You are the user and controller of your genes, the author of your biological story. No prospect in self-care is more exciting."
Learning how to shape your gene activity is at the heart of this exciting and eagerly-anticipated book from the bestselling duo behind Super Brain, which became a nationwide hit on public television.
For decades medical science has believed that genes determined our biological destiny. Now the new genetics has changed that assumption forever. You will always have the genes you were born with, but genes are dynamic, responding to everything we think, say, and do. Suddenly they've become our strongest allies for personal transformation. When you make lifestyle choices that optimize how your genes behave, you can reach for a state of health and fulfillment undreamed of even a decade ago. The impact on prevention, immunity, diet, aging, and chronic disorders is unparalleled.



