We are at the beginning of a new era for Alzheimer’s driven by the development of increasingly powerful diagnostic tools. General practitioners will be able to screen people for early-stage Alzheimer’s and treat the disease before damage occurs. That means we can preserve memories and maintain a higher quality of life for those at risk.
Many of the drug combinations evaluated in Alzheimer’s-in-a-Dish™ have already received FDA approval for safety in other indications.
Because the testing process is dramatically shorter, it also costs less.
Because of the availability of affordable products, they will be more accessible to more of the population, improving brain health for all, not just the wealthy who can afford a higher level of care.
Dr. Tanzi’s Alzheimer’s-in-a-Dish™ has revolutionized drug screening, making it faster and more affordable. Using mini human brain organoids, he and his team have screened FDA-approved drugs and thousands of natural products, uncovering new possibilities for preventing and treating Alzheimer’s.
Dr. Tanzi has pioneered an innovative drug, a next-generation gamma secretase modulator, designed to reduce beta-amyloid production and address the excess build-up of beta-amyloid plaques. Hailed as a transformative step forward, it offers new hope as a safer, more effective alternative to current treatments. With a Phase 1 clinical trial on the horizon, this breakthrough brings renewed optimism for the future of brain health.
GSMs may have preventive applications in reducing excess amyloid accumulation before symptom onset, analogous to statins for cardiovascular health.
Dr. Tanzi’s GSM uses a novel mechanism to reduce excess amyloid, with the potential to be much safer than amyloid immunotherapy and contribute to clinical benefit.
Ideally, proactive screening will prevent the accumulation of amyloid before people experience neuroinflammation.
A Brighter Future for Brain Health
We could continue to pursue our passions, nurture relationships, and contribute to society with clarity and energy well into old age. Free from the constraints of debilitating cognitive diseases, the future would be one where memories are preserved, creativity thrives, and our minds remain as strong as our bodies. Make brain care a top priority.
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